Evaluation of the Impact Induced by High Dietary Sucrose Concentration and Glucocorticoid Medication on Dentin Formation of Young Rats

Oancea, Roxana; Funieru, Cristian; Sfeatcu, Ruxandra; Vaduva, Delia Berceanu; Cheveresan, Adelina

Roxana Oancea, Cristian Funieru, Ruxandra Sfeatcu, Delia Berceanu Vaduva, Adelina Cheveresan

Evaluation of the Impact Induced by High Dietary Sucrose Concentration and Glucocorticoid Medication on Dentin Formation of Young Rats

Abstract:

The impact of sucrose and systemic cortisone treatment on the response of dentin was examined in an experimental rat model. After 2 months of a modified diet and/or medication period, the areas of dentin formation and dentinal caries were quantified in the mandibular molars of growing animals. The 60% sucrose diet significantly reduced dentin formation and increased dentinal caries progression. The presence of glucocorticoid medication alone reduced dentin formation. Cortisone medication in combination with sucrose diet further decreased dentin apposition. Rats receiving the control diet positively responded to the dentinal caries by increasing dentin formation to prevent pulpal exposure. The rate of dentine formation was lower in rats with high sucrose diet and predentin area was wider compared to the control group fed normal diet. The enlargement of the predentin region in sucrose diet rats reflects changes in the functionality of the odontoblasts, such as reduction of matrix synthesis and alteration of the mineralization process. These results indicate that the functional alterations in the pulpo-dentinal complex might contribute to dentinal caries progression through systemic mechanism irrespective of the causative factors.

Keywords:
diet; sucrose; cortisone; dentin

Issue: 2019, Volume 70, Issue 10

Pages: 3714-3718

Publication date: 2019/11/15

https://doi.org/10.37358/RC.19.10.7631

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
OANCEA, R., FUNIERU, C., SFEATCU, R., VADUVA, D.B., CHEVERESAN, A., Evaluation of the Impact Induced by High Dietary Sucrose Concentration and Glucocorticoid Medication on Dentin Formation of Young Rats, Rev. Chim., 70(10), 2019, 3714-3718.

Vancouver
Oancea R, Funieru C, Sfeatcu R, Vaduva DB, Cheveresan A. Evaluation of the Impact Induced by High Dietary Sucrose Concentration and Glucocorticoid Medication on Dentin Formation of Young Rats. Rev. Chim.[internet]. 2019 Oct;70(10):3714-3718. Available from: https://doi.org/10.37358/RC.19.10.7631

APA 6th edition
Oancea, R., Funieru, C., Sfeatcu, R., Vaduva, D.B. & Cheveresan, A. (2019). Evaluation of the Impact Induced by High Dietary Sucrose Concentration and Glucocorticoid Medication on Dentin Formation of Young Rats. Revista de Chimie, 70(10), 3714-3718. https://doi.org/10.37358/RC.19.10.7631

Harvard
Oancea, R., Funieru, C., Sfeatcu, R., Vaduva, D.B., Cheveresan, A. (2019). 'Evaluation of the Impact Induced by High Dietary Sucrose Concentration and Glucocorticoid Medication on Dentin Formation of Young Rats', Revista de Chimie, 70(10), pp. 3714-3718. https://doi.org/10.37358/RC.19.10.7631

IEEE
R. Oancea, C. Funieru, R. Sfeatcu, D.B. Vaduva, A. Cheveresan, "Evaluation of the Impact Induced by High Dietary Sucrose Concentration and Glucocorticoid Medication on Dentin Formation of Young Rats". Revista de Chimie, vol. 70, no. 10, pp. 3714-3718, 2019. [online]. https://doi.org/10.37358/RC.19.10.7631

Text
Roxana Oancea, Cristian Funieru, Ruxandra Sfeatcu, Delia Berceanu Vaduva, Adelina Cheveresan,
Evaluation of the Impact Induced by High Dietary Sucrose Concentration and Glucocorticoid Medication on Dentin Formation of Young Rats,
Revista de Chimie,
Volume 70, Issue 10,
2019,
Pages 3714-3718,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.10.7631.
(https://revistadechimie.ro/Articles.asp?ID=7631)
Keywords: diet; sucrose; cortisone; dentin

RIS
TY - JOUR
T1 - Evaluation of the Impact Induced by High Dietary Sucrose Concentration and Glucocorticoid Medication on Dentin Formation of Young Rats
A1 - Oancea, Roxana
A2 - Funieru, Cristian
A3 - Sfeatcu, Ruxandra
A4 - Vaduva, Delia Berceanu
A5 - Cheveresan, Adelina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 10
SP - 3714
EP - 3718
UR - https://doi.org/10.37358/RC.19.10.7631
KW - diet
KW - sucrose
KW - cortisone
KW - dentin
ER -

BibTex
@article{RevCh2019P3714,
author = {Oancea Roxana and Funieru Cristian and Sfeatcu Ruxandra and Vaduva Delia Berceanu and Cheveresan Adelina},
title = {Evaluation of the Impact Induced by High Dietary Sucrose Concentration and Glucocorticoid Medication on Dentin Formation of Young Rats},
journal = {Revista de Chimie},
volume = {70},
number = {10},
pages = {3714-3718},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.10.7631},
url = {https://revistadechimie.ro/Articles.asp?ID=7631}
}

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