CYCLIZATION OF SOME NEW N1-AROYL N4 – ARYL-THIOSEMICARBAZIDES
Some new thiosemicarbazides (3a-d) with potential tuberculostatic activity were synthesized using classical procedures. Cyclization of (3a,b) in sodium hidroxide medium afforded the corresponding 1,2,4-triazole-3-thioles (4a,b). Cyclization of (3a-d) in sulfuric acid 98% medium afforded the corresponding 2-aminoaryl-1,3,4-thiadiazoles (5a-d). All the new compounds were extensively characterized by IR-, UV-, 1H-NMR and 13C-NMR spectroscopy and were investigated using fitobiological tests.