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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 7, 2566-2570

https://doi.org/10.37358/RC.19.7.7381

Dragos Botezatu, Cristina Popescu, Andrei-Dan Korodi, Cristian Furau, Gheorghe Furau, Bogdan Socea, Crangu Ionescu, Mihai Dimitriu, Diana Claudia Gheorghiu, Nicolae Gheorghiu, Ioiart Ioan

Importance of Genetic Factors in Male Fertility Disorders, Clinical Relevance of Epigenetic Markers in Male Infertility

Abstract:

Male infertility is a common and complex problem affecting 1 out of 20 men. Despite extensive research in this area, in many cases, the underlying causes are unknown. Epigenetic changes control a series of processes within the body, including male fertility. Classification of infertile men using a more detailed analysis of DNA methylation patterns could reveal a new level of low rates of fertilization, implantation, or pregnancy. In this context, it seemed to us to use the techniques available to evaluate the degree of global methylation of DNA in infertile patients who have modified sperm counts, but also those who apparently do not have a clear cause of infertility. For this we used the Quest 5mC-Zymoresaerch-ELISA kit that can detect within about 5 hours the global level of genome methylation. Claims on which common illnesses have an epigenetic base are still open to speculation, but if true, it can imprint a new direction in medicine. Our data, although from a pilot study, are consistent with those in the literature. A recent study has shown that DNA methylation levels were significantly higher in oligoasthenoteratozoospermia patients than in the control group and the increase in global DNA methylation and histone retention in men with oligoasthenoteratozoospermia.
Keywords:
male infertility; epigenetic markers; DNA methylation (5mC)

Issue: 2019, Volume 70, Issue 7
Pages: 2566-2570
Publication date: 2019/8/15
https://doi.org/10.37358/RC.19.7.7381
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
BOTEZATU, D., POPESCU, C., KORODI, A., FURAU, C., FURAU, G., SOCEA, B., IONESCU, C., DIMITRIU, M., GHEORGHIU, D.C., GHEORGHIU, N., IOAN, I., Importance of Genetic Factors in Male Fertility Disorders, Clinical Relevance of Epigenetic Markers in Male Infertility, Rev. Chim., 70(7), 2019, 2566-2570.

Vancouver
Botezatu D, Popescu C, Korodi A, Furau C, Furau G, Socea B, Ionescu C, Dimitriu M, Gheorghiu DC, Gheorghiu N, Ioan I. Importance of Genetic Factors in Male Fertility Disorders, Clinical Relevance of Epigenetic Markers in Male Infertility. Rev. Chim.[internet]. 2019 Jul;70(7):2566-2570. Available from: https://doi.org/10.37358/RC.19.7.7381


APA 6th edition
Botezatu, D., Popescu, C., Korodi, A., Furau, C., Furau, G., Socea, B.,... Ioan, I. (2019). Importance of Genetic Factors in Male Fertility Disorders, Clinical Relevance of Epigenetic Markers in Male Infertility. Revista de Chimie, 70(7), 2566-2570. https://doi.org/10.37358/RC.19.7.7381


Harvard
Botezatu, D., Popescu, C., Korodi, A., Furau, C., Furau, G., Socea, B., Ionescu, C., Dimitriu, M., Gheorghiu, D.C., Gheorghiu, N., Ioan, I. (2019). 'Importance of Genetic Factors in Male Fertility Disorders, Clinical Relevance of Epigenetic Markers in Male Infertility', Revista de Chimie, 70(7), pp. 2566-2570. https://doi.org/10.37358/RC.19.7.7381


IEEE
D. Botezatu, C. Popescu, A. Korodi, C. Furau, G. Furau, B. Socea, C. Ionescu, M. Dimitriu, D.C. Gheorghiu, N. Gheorghiu, I. Ioan, "Importance of Genetic Factors in Male Fertility Disorders, Clinical Relevance of Epigenetic Markers in Male Infertility". Revista de Chimie, vol. 70, no. 7, pp. 2566-2570, 2019. [online]. https://doi.org/10.37358/RC.19.7.7381


Text
Dragos Botezatu, Cristina Popescu, Andrei-Dan Korodi, Cristian Furau, Gheorghe Furau, Bogdan Socea, Crangu Ionescu, Mihai Dimitriu, Diana Claudia Gheorghiu, Nicolae Gheorghiu, Ioiart Ioan,
Importance of Genetic Factors in Male Fertility Disorders, Clinical Relevance of Epigenetic Markers in Male Infertility,
Revista de Chimie,
Volume 70, Issue 7,
2019,
Pages 2566-2570,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.7.7381.
(https://revistadechimie.ro/Articles.asp?ID=7381)
Keywords: male infertility; epigenetic markers; DNA methylation (5mC)


RIS
TY - JOUR
T1 - Importance of Genetic Factors in Male Fertility Disorders, Clinical Relevance of Epigenetic Markers in Male Infertility
A1 - Botezatu, Dragos
A2 - Popescu, Cristina
A3 - Korodi, Andrei-Dan
A4 - Furau, Cristian
A5 - Furau, Gheorghe
A6 - Socea, Bogdan
A7 - Ionescu, Crangu
A8 - Dimitriu, Mihai
A9 - Gheorghiu, Diana Claudia
A10 - Gheorghiu, Nicolae
A11 - Ioan, Ioiart
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 7
SP - 2566
EP - 2570
UR - https://doi.org/10.37358/RC.19.7.7381
KW - male infertility
KW - epigenetic markers
KW - DNA methylation (5mC)
ER -


BibTex
@article{RevCh2019P2566,
author = {Botezatu Dragos and Popescu Cristina and Korodi Andrei-Dan and Furau Cristian and Furau Gheorghe and Socea Bogdan and Ionescu Crangu and Dimitriu Mihai and Gheorghiu Diana Claudia and Gheorghiu Nicolae and Ioan Ioiart},
title = {Importance of Genetic Factors in Male Fertility Disorders, Clinical Relevance of Epigenetic Markers in Male Infertility},
journal = {Revista de Chimie},
volume = {70},
number = {7},
pages = {2566-2570},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.7.7381},
url = {https://revistadechimie.ro/Articles.asp?ID=7381}
}
 
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