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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 8, 2737-2741

https://doi.org/10.37358/RC.19.8.7418

Hajnal Kelemen, Gabriel Hancu, Bernadette Mentes, Ibolya Fulop, Melania Carcu Dobrin, Daniela Lucia Muntean, Eleonora Mircia

Characterization of Inclusion Complexes Between Fluconazol and Different Cyclodextrin Derivatives

Abstract:

The aim of this study is to confirm the formation of inclusion complexes between fluconazoleand different cyclodextrin derivatives. Fluconazole is slightly soluble in water, but its solubility can be further increased by complexation with cyclodextrins. The binary systems between fluconazole and cyclodextrins were prepared in 1:1 molar ratios by physical-mixture method and kneading method. Differential scanning calorimetry (DSC), Fourier transformed-infrared spectroscopy (FT-IR) and molecular modeling methods were used to characterize solid state interactions between fluconazole and cyclodextrins in their binary systems. The analysis suggest the formation of a new solid phase, indicating a molecular interaction between the components. All binary systems showed superior dissolution profiles compared to pure fluconazole.
Keywords:
fluconazole; cyclodextrins; differential scanning calorimetry; Fourier transform -infrared spectroscopy; solubility

Issue: 2019, Volume 70, Issue 8
Pages: 2737-2741
Publication date: 2019/9/15
https://doi.org/10.37358/RC.19.8.7418
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
KELEMEN, H., HANCU, G., MENTES, B., FULOP, I., DOBRIN, M.C., MUNTEAN, D.L., MIRCIA, E., Characterization of Inclusion Complexes Between Fluconazol and Different Cyclodextrin Derivatives, Rev. Chim., 70(8), 2019, 2737-2741.

Vancouver
Kelemen H, Hancu G, Mentes B, Fulop I, Dobrin MC, Muntean DL, Mircia E. Characterization of Inclusion Complexes Between Fluconazol and Different Cyclodextrin Derivatives. Rev. Chim.[internet]. 2019 Aug;70(8):2737-2741. Available from: https://doi.org/10.37358/RC.19.8.7418


APA 6th edition
Kelemen, H., Hancu, G., Mentes, B., Fulop, I., Dobrin, M.C., Muntean, D.L. & Mircia, E. (2019). Characterization of Inclusion Complexes Between Fluconazol and Different Cyclodextrin Derivatives. Revista de Chimie, 70(8), 2737-2741. https://doi.org/10.37358/RC.19.8.7418


Harvard
Kelemen, H., Hancu, G., Mentes, B., Fulop, I., Dobrin, M.C., Muntean, D.L., Mircia, E. (2019). 'Characterization of Inclusion Complexes Between Fluconazol and Different Cyclodextrin Derivatives', Revista de Chimie, 70(8), pp. 2737-2741. https://doi.org/10.37358/RC.19.8.7418


IEEE
H. Kelemen, G. Hancu, B. Mentes, I. Fulop, M.C. Dobrin, D.L. Muntean, E. Mircia, "Characterization of Inclusion Complexes Between Fluconazol and Different Cyclodextrin Derivatives". Revista de Chimie, vol. 70, no. 8, pp. 2737-2741, 2019. [online]. https://doi.org/10.37358/RC.19.8.7418


Text
Hajnal Kelemen, Gabriel Hancu, Bernadette Mentes, Ibolya Fulop, Melania Carcu Dobrin, Daniela Lucia Muntean, Eleonora Mircia,
Characterization of Inclusion Complexes Between Fluconazol and Different Cyclodextrin Derivatives,
Revista de Chimie,
Volume 70, Issue 8,
2019,
Pages 2737-2741,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.8.7418.
(https://revistadechimie.ro/Articles.asp?ID=7418)
Keywords: fluconazole; cyclodextrins; differential scanning calorimetry; Fourier transform -infrared spectroscopy; solubility


RIS
TY - JOUR
T1 - Characterization of Inclusion Complexes Between Fluconazol and Different Cyclodextrin Derivatives
A1 - Kelemen, Hajnal
A2 - Hancu, Gabriel
A3 - Mentes, Bernadette
A4 - Fulop, Ibolya
A5 - Dobrin, Melania Carcu
A6 - Muntean, Daniela Lucia
A7 - Mircia, Eleonora
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 8
SP - 2737
EP - 2741
UR - https://doi.org/10.37358/RC.19.8.7418
KW - fluconazole; cyclodextrins; differential scanning calorimetry; Fourier transform -infrared spectroscopy; solubility
ER -


BibTex
@article{RevCh2019P2737,
author = {Kelemen Hajnal and Hancu Gabriel and Mentes Bernadette and Fulop Ibolya and Dobrin Melania Carcu and Muntean Daniela Lucia and Mircia Eleonora},
title = {Characterization of Inclusion Complexes Between Fluconazol and Different Cyclodextrin Derivatives},
journal = {Revista de Chimie},
volume = {70},
number = {8},
pages = {2737-2741},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.8.7418},
url = {https://revistadechimie.ro/Articles.asp?ID=7418}
}
 
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