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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 8, 3003-3007

https://doi.org/10.37358/RC.19.8.7474

Ileana Marinescu, Puiu Olivian Stovicek, Dragos Marinescu, Marius Toma Papacocea, Mihnea Costin Manea, Ecaterina Ionescu, Ioana Anca Badarau, Mirela Manea, Ioana Raluca Papacocea, Adela Magdalena Ciobanu

Cinnarizine - Potential Trigger of the Dopamine Supersensitivity Psychosis in Patients with Paranoid Schizophrenia Particular neurobiochemical model

Abstract:

Supersensitivity psychosis is a subdiagnosed clinical reality. This entity, however, is insufficiently elucidated from the point of view of the neurobiochemical mechanisms involved in the pathogenesis. The combination of an antipsychotic with a high D2 receptor blocking capacity and a neuroleptic-like substance such as cinnarizine trigger the dopaminergic hypersensitivity mechanisms. This stimulates the sensitivity for dopamine in the prefrontal cortex, ameliorating the negative and cognitive symptoms at the thalamic level, remodeling sensory integration and decreasing tinnitus, as well as in the cerebral tonsil, consequently decreasing the risk of antisocial behavior.
Keywords:
cinnarizine; dopamine; supersensitivity psychosis; antipsychotics

Issue: 2019, Volume 70, Issue 8
Pages: 3003-3007
Publication date: 2019/9/15
https://doi.org/10.37358/RC.19.8.7474
download pdf   Download Pdf Article
Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
MARINESCU, I., STOVICEK, P.O., MARINESCU, D., PAPACOCEA, M.T., MANEA, M.C., IONESCU, E., BADARAU, I.A., MANEA, M., PAPACOCEA, I.R., CIOBANU, A.M., Cinnarizine - Potential Trigger of the Dopamine Supersensitivity Psychosis in Patients with Paranoid Schizophrenia Particular neurobiochemical model, Rev. Chim., 70(8), 2019, 3003-3007.

Vancouver
Marinescu I, Stovicek PO, Marinescu D, Papacocea MT, Manea MC, Ionescu E, Badarau IA, Manea M, Papacocea IR, Ciobanu AM. Cinnarizine - Potential Trigger of the Dopamine Supersensitivity Psychosis in Patients with Paranoid Schizophrenia Particular neurobiochemical model. Rev. Chim.[internet]. 2019 Aug;70(8):3003-3007. Available from: https://doi.org/10.37358/RC.19.8.7474


APA 6th edition
Marinescu, I., Stovicek, P.O., Marinescu, D., Papacocea, M.T., Manea, M.C., Ionescu, E.,... Ciobanu, A.M. (2019). Cinnarizine - Potential Trigger of the Dopamine Supersensitivity Psychosis in Patients with Paranoid Schizophrenia Particular neurobiochemical model. Revista de Chimie, 70(8), 3003-3007. https://doi.org/10.37358/RC.19.8.7474


Harvard
Marinescu, I., Stovicek, P.O., Marinescu, D., Papacocea, M.T., Manea, M.C., Ionescu, E., Badarau, I.A., Manea, M., Papacocea, I.R., Ciobanu, A.M. (2019). 'Cinnarizine - Potential Trigger of the Dopamine Supersensitivity Psychosis in Patients with Paranoid Schizophrenia Particular neurobiochemical model', Revista de Chimie, 70(8), pp. 3003-3007. https://doi.org/10.37358/RC.19.8.7474


IEEE
I. Marinescu, P.O. Stovicek, D. Marinescu, M.T. Papacocea, M.C. Manea, E. Ionescu, I.A. Badarau, M. Manea, I.R. Papacocea, A.M. Ciobanu, "Cinnarizine - Potential Trigger of the Dopamine Supersensitivity Psychosis in Patients with Paranoid Schizophrenia Particular neurobiochemical model". Revista de Chimie, vol. 70, no. 8, pp. 3003-3007, 2019. [online]. https://doi.org/10.37358/RC.19.8.7474


Text
Ileana Marinescu, Puiu Olivian Stovicek, Dragos Marinescu, Marius Toma Papacocea, Mihnea Costin Manea, Ecaterina Ionescu, Ioana Anca Badarau, Mirela Manea, Ioana Raluca Papacocea, Adela Magdalena Ciobanu,
Cinnarizine - Potential Trigger of the Dopamine Supersensitivity Psychosis in Patients with Paranoid Schizophrenia Particular neurobiochemical model,
Revista de Chimie,
Volume 70, Issue 8,
2019,
Pages 3003-3007,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.8.7474.
(https://revistadechimie.ro/Articles.asp?ID=7474)
Keywords: cinnarizine; dopamine; supersensitivity psychosis; antipsychotics


RIS
TY - JOUR
T1 - Cinnarizine - Potential Trigger of the Dopamine Supersensitivity Psychosis in Patients with Paranoid Schizophrenia Particular neurobiochemical model
A1 - Marinescu, Ileana
A2 - Stovicek, Puiu Olivian
A3 - Marinescu, Dragos
A4 - Papacocea, Marius Toma
A5 - Manea, Mihnea Costin
A6 - Ionescu, Ecaterina
A7 - Badarau, Ioana Anca
A8 - Manea, Mirela
A9 - Papacocea, Ioana Raluca
A10 - Ciobanu, Adela Magdalena
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 8
SP - 3003
EP - 3007
UR - https://doi.org/10.37358/RC.19.8.7474
KW - cinnarizine
KW - dopamine
KW - supersensitivity psychosis
KW - antipsychotics
ER -


BibTex
@article{RevCh2019P3003,
author = {Marinescu Ileana and Stovicek Puiu Olivian and Marinescu Dragos and Papacocea Marius Toma and Manea Mihnea Costin and Ionescu Ecaterina and Badarau Ioana Anca and Manea Mirela and Papacocea Ioana Raluca and Ciobanu Adela Magdalena},
title = {Cinnarizine - Potential Trigger of the Dopamine Supersensitivity Psychosis in Patients with Paranoid Schizophrenia Particular neurobiochemical model},
journal = {Revista de Chimie},
volume = {70},
number = {8},
pages = {3003-3007},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.8.7474},
url = {https://revistadechimie.ro/Articles.asp?ID=7474}
}
 
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