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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2006, Volume 57, Issue 10,





Determination of the Structural Interaction
of Nifluminic Acid-PVP Solid Dispersions

Abstract:

Poorly water-soluble drugs, such as nifluminic acid -important anti-inflammatory drug- offer challenging problems in drug formulation as poor solubility is generally associated to poor dissolution characteristic and thus, to poor oral bioavailibility. In order to increase the degree of dissolution and solubility of nifluminic acid, products were prepared with polyvinylpyrrolidone K-25, using physical mixing and solvent evaporation methods . The drug-polymer interactions in the solid state were investigated by using hot-stage microscopy, differential scanning calorimetry, Fourier transform infrared spectroscopy and X-ray powder diffraction. The results suggested that polyvinylpyrrolidone may inhibit the association of the drug molecule to form the crystal nucleus and, thereby inhibit crystal growth. In the physical mixtures, the nifluminic acid was dissolved in the melted polyvinylpyrrolidone, whereas the solid dispersions contained nifluminic acid in the amorphous state. Keywords: solid dispersion; FT-IR; X-ray powder diffraction; thermoanalytical investigations nifluminic acid; polyvinylpyrrolidone


Issue: 2006, Volume 57, Issue 10
Pages:
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