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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2007, Volume 58, Issue 6,





Simulation of Transport Processes of Antibiotics

Abstract:

In recent years, it has become increasingly apparent that many of the methods used in the field of chemical engineering are applicable to the problems of living systems. In the pharmacokinetic practice, it is important to know the concentration-time profile of antibiotics in tissues, since most infections start and progress outside the vascular bed. Complex processes acting simultaneously and interdependently determine drug distribution. These problems may be solved through the application of modern engineering methods. Many mathematical models have been proposed in the medical and chemical engineering literature, for describing the transport and distribution of antibiotics. The passive diffusion is the most important transport mode of antibiotics in lungs. In the present paper, a simulation study of the Cefazolin penetration in the pulmonary tissue of rabbits, on the basis of a diffusional model, is reported. The computation of the concentration-time profiles of Cefazolin i.v. administrated in the lung parenchyma, could be important for prediction of the therapeutic efficacy of the antibiotic treatment in bacterial respiratory tract infections. Key words: antibiotic diffusion, pulmonary tissue, Cefazolin, simulation study


Issue: 2007, Volume 58, Issue 6
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