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Revista de Chimie (Rev. Chim.), Year 2007, Volume 58, Issue 12,





Functional Analysis of Human Gene Promoters

Abstract:

The complexity of gene control processes and the perspectives opened by understanding how to control a target gene are several important reasons for researchers to try to find out more information about gene control mechanisms and the molecular networks responsible for that. The promoter is a central part of the regulatory network, being responsible for the transcription initiation process. The functional analysis of human promoters comprises combinations of methods that connect the special organizational features of the human promoters with the aspects of gene control by investigating in vivo and in vitro interactions. Combining data from different approaches, the functional analysis of the promoter represents the key to understand the gene control process, the mechanisms and molecular networks involved. Consequently, these helps to define the therapeutic strategies to be adopted in the case of a particular disease to control the expression of the genes associated with that disease. Keywords: gene control promoter, transcription factors, computational, functional analysis


Issue: 2007, Volume 58, Issue 12
Pages:
Publication date: 2001/1/1
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