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Revista de Chimie (Rev. Chim.), Year 2008, Volume 59, Issue 4,

https://doi.org/10.37358/RC.08.4.1793

Adrian Rivis, Ariana-Bianca Velciov, Zeno Garban, Corina Costescu, Ileana Nichita

Influence of cis-Platinum Administration at Different Doses on Zinc, Cooper and Iron Concentration in Hapatic Tissue

Abstract:

Interactions between metal ions and biological systems have many implications. Based on these facts, several platinum compounds have been obtained and evaluated as chemotherapeutical agents. It is generally believed that the anticancerous effects of cis-platinum are based on interactions with DNA. Our study is trying to reveal the interrelations between concentration of some metallic ions from hepatic tissue and different doses of cis-platinum (cDDP). The cytotoxic activity of cis-platinum can be correlate with the levels of platinum that bounds to DNA. For the experimental part, we used adults animals from Wistar rats strain divided in four experimental groups and one control group. Wistar rats from the experimental groups were injected intraperitoneally (i.p.) with cis-platinum (the drug called Sin-Platinum) in study days 3 and 8. The animals from control group were injected with saline solution (placebo), also in study days 3 and 8. The results showed that the concentration of metal ions in liver is modified proportionally with administrated doses.

Keywords:
cis-platinum; metallic ions; adducts metals-DNA

Issue: 2008, Volume 59, Issue 4
Pages:
Publication date: 2008/5/9
https://doi.org/10.37358/RC.08.4.1793
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