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Revista de Chimie (Rev. Chim.), Year 2008, Volume 59, Issue 7,

https://doi.org/10.37358/RC.08.7.1881

Daniela Lucia Muntean, Silvia Imre, Cosmina Voda

The Influence of Some Factors on Spirolactone Stability in Solution

Abstract:

The influence of some factors on spironolactone stability in solution was studied, by applying high-performance liquid chromatography, as a part of a pharmaceutical preformulation study in order to obtain a spironolactone solution for alopecia treatment. Solutions of 1 mg/ml spironolactone in aqueous ethanolic solution 1 : 1 and in 20 mM cyclodextrines solutions (b-, hydroxi-b- and methyl-b-cyclodextrine) was used, maintained at 8 and 22 °C, protected from light and after UV irradiation at 254 nm. The main degradation products were 7a-thiospirolactone and canrenone. The most stable solutions were the alcoholic ones and with methyl-beta-cyclodextrine, but the simultaneous action of temperature and UV irradiation allowed degradation processes after one hour of exposure, more aggressive in the presence of methyl-beta-cyclodextrine. In conclusion, for alopecia treatment with spironolactone a 1 mg/mL ethanolic solution could be used and it is recommendable the protection of treated zone.

Keywords:
spironolactone; cyclodextrines; stability

Issue: 2008, Volume 59, Issue 7
Pages:
Publication date: 2008/8/9
https://doi.org/10.37358/RC.08.7.1881
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