CODRUTA COFAN, CIPRIAN RADOVAN, DAN CINGHITA<br>Simultaneous Anodic Assessment of Ascorbic Acid <br>and Acetaminophen in Unbuffered Solutions<br>

CODRUTA COFAN, CIPRIAN RADOVAN, DAN CINGHITA
Simultaneous Anodic Assessment of Ascorbic Acid
and Acetaminophen in Unbuffered Solutions

Abstract:

The simultaneous detection of L-ascorbic acid (AA) and acetaminophen (AC) at a boron-doped diamond electrode (BDDE), in a sodium sulphate supporting electrolyte, using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) was investigated. The calibration plots resulting from two distinct series of anodic current peaks versus concentration of AA and AC in single and di-component systems, obtained from CV and DPV data, presented linearity, with very good correlation coefficients. Fouling of the electrode surface was not evident and BDDE showed very reproducible voltammetric signals in all investigated situations. The relative standard deviations of 2 -3 %, high sensitivity values, and low limits of detection evaluated from DPV data in single systems, have been practically recovered in di-component standard and real sample solutions. The anodic assessment with the use of DPV was additionally verified by the simultaneous determination of AA and AC in real samples prepared from pharmaceutical products. Using a very simple supporting electrolyte, neutral unbuffered sodium sulphate solution, the DPV at a BDDE was confirmed as an easily applicable electroanalytical option. Individual and average values corresponding to AA and AC content in an investigated pharmaceutical product were determined by DPV coupled with standard addition method giving results in good accordance with the composition indicated by the supplier. Keywords: acetaminophen, ascorbic acid, differential pulse voltammetry, unbuffered media, boron-doped diamond electrode

Issue: 2009, Volume 60, Issue 4

Pages:

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