Bogdan Tita, Adriana Fulias, Gerlinde Rusu, Dumitru Tita<br>Thermal Behaviour of Indomethacin - Active Substance and Tablets<br>Kinetic Study Under Non-Isothermal Conditions

Bogdan Tita, Adriana Fulias, Gerlinde Rusu, Dumitru Tita
Thermal Behaviour of Indomethacin - Active Substance and Tablets
Kinetic Study Under Non-Isothermal Conditions

Abstract:

Thermal analysis is one of the most widely used methods for studying the solid state of pharmaceutical substances. TG/DTG and DSC curves provide important information regarding the physical properties of the pharmaceutical compounds (stability, compatibility, polymorphism, kinetic analysis, phase transitions etc). The evaluation of thermal stability in the solid state is mostly made by analysing their decomposition under isothermal or non-isothermal conditions. The purpose of a kinetic investigation is to calculate the kinetic parameters and the kinetic model for the studied process. The results are further used to predict the system’s behaviour in various circumstances. The present work reports the study of thermal behaviour of indomethacin active substance and tablets, together with a determination of the melting point, respectively the determination of the kinetic parameters under non-isothermal conditions. The kinetic parameters of the decomposition were obtained on TG and DSC curves using the following differential methods: Chang and Friedman isoconversional (Fd), respectively integral methods: Coats-Redfern (CR), Kissinger-Akahira-Sunrose (KAS) and Flynn-Wall-Ozawa (FWO). The results obtained show that the indomethacin tablets are thermally more stable than the active substance. The increase in stability was attributed to the presence of excipients in formulation. Keywords: thermal stability, indomethacin, kinetic study, TG/DTG, DSC, kinetic parameters

Issue: 2009, Volume 60, Issue 11

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