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REVISTA DE CHIMIE
https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie, Volume 61, Issue 1, pp. (2010)




Gabriela Carja, Sofronia Dranca, Gabriela Lehutu Stabilization of Cefotaxime in Hydrotalcite - Like Anionic Clay Matrix and its Controlled Release

Abstract:

The incorporation of cefotaxime in the brucite (Mg(OH)2)-like inorganic network gives rise to a hybrid pharmaceutical formulation that contains both the properties of inorganic clay and the drug in a single material. The structural properties of the drug - clay assembly are described by using the results of X-ray diffraction, FTIR and TGA-DTA analyses. The TEM micrographs give information about the micromorphology features of the hybrid structures pointing out to the exfoliation of the clay layers. The drug content of the new designed pharmaceutical formulation is a function of the characteristics of the synthesis method. The confinement of the drug inside the clay matrix is stable up to 130 °C while its sustained release is a slow process. The results point out to an improved stability of the drug in the hybrid formulation as well as the possibilities to tailor its release behaviour as a function of the synthesis procedure. Keywords: drug delivery, cefotaxime, drug-clay assembly, controlled release

Issue: 2010 Volume 61, Number 1
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