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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2010, Volume 61, Issue 1,





DUMITRU POPESCU, DUMITRU PETRU IGA
Transmembrane Delivery of Biologically Active
Substances by Pulsatory Liposomes

Abstract:

The running of a biological device, named pulsatory liposome is described. In a hypotonic external medium a liposome is swelling up to a critical size, and then suddenly one transmembrane pore is formed. A part of the internal constituents, genetic material, drugs or other biologically active compounds, comes out of the liposome through this transmembrane pore. In the first part of its evolution, the pore increases, then decreases, and finally it is closed. The kinetic process described above is resumed, becoming a cyclic one. The amount of substance delivered in each cycle, the number of cycles per time unit and their duration have been calculated. Keywords: pulsatory liposome, transmembrane transport, transient pore, drug delivery

Issue: 2010, Volume 61, Issue 1
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