DORINA CASONI, CODRUTA SIMONA COBZAC, COSTEL SARBU<br>A Comparative Study Concerning the Lipophilicity of Some <br>Synthetic Dyes Estimated by Thin Layer Chromatography <br>and Different Computation Methods

DORINA CASONI, CODRUTA SIMONA COBZAC, COSTEL SARBU
A Comparative Study Concerning the Lipophilicity of Some
Synthetic Dyes Estimated by Thin Layer Chromatography
and Different Computation Methods

Abstract:

The retention behaviour of some selected synthetic dyes have been investigated on RP-18F254S, RP-18W/UV254 and CNF254S plates using methanol-water mixture in different volume proportions as mobile phases. The RM values of the compounds decreased linearly with increasing concentration of methanol in the mobile phase in all cases. On the basis of the linear relationship between retention (RM) values and volume fraction of methanol, values of RM0 corresponding to 100% water were obtained by extrapolation using five isocratic RM values. The regression determination coefficients obtained for all stationary phases were excellent (higher than 0.99 in all cases). The good regularities of profiles of retention indices (RM and PC1/RM) indicated that the same mechanism (lipophilic interactions) is dominant in all cases and all types of stationary phases (RP-18, RP-18W and CN) appear to be suitable for estimating the lipophilicity of selected synthetic dyes. The chromatographic lipophilicity values (expressed by RM0) estimated on three different stationary phases were not highly correlated between them and also with computed log P values. The best correlations were founded with lipophilicity parameters calculated by Dragon 5.4 software. By using PC1/RM or j0 values as estimators for lipophilic character of synthetic dyes, the correlation between these values obtained on that three stationary phases were significantly improved, correlation coefficient being higher than 0.92 in some cases. Keywords: lipophilicity, synthetic dyes, computed log P, RP-HPTLC, PCA

Issue: 2010, Volume 61, Issue 3

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This article is published under the Creative Commons Attribution 4.0 International License

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