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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2010, Volume 61, Issue 12,





ADRIANA FULIAS, TITUS VLASE, GABRIELA VLASE, ZOLTAN SZABADAI, GERLINDE RUSU, GEZA BANDUR, DUMITRU TITA, NICOLAE DOCA
Thermoanalytical Study of Cefadroxil and its Mixtures with Different Excipients

Abstract:

In this study, it was studied the thermal decomposition of cefadroxil and some mixture with excipients containing the same active compound using TG/ DTG and DSC techniques. The kinetic parameters were obtained from DSC curves using the Flynn-Wall-Ozawa method, respectively a nitrogen dynamic atmosphere and different heating rates. The kinetic data showed that the cefadroxil-active substance is thermally more stable than the mixtures with any excipient. The decrease in stability was attributed to the presence of excipients in formulation and to their possible interactions with the cefadroxil. The difference in stability is bigger between the pure substance and the mixture with the magnesium stearate. Keywords: cefadroxil; degradation behaviour; excipient; activation energy


Issue: 2010, Volume 61, Issue 12
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