Germaine Savoiu Balint, Claudia Borza, Carmen Cristescu, Mihaiela Andoni,  Georgeta Maria Simu, Daniel Malita, Ioana  Malita, Adelina Cheveresan<br>Endogenous and Exogenous Antioxidant Protection <br>for Endothelial Dysfunction

Germaine Savoiu Balint, Claudia Borza, Carmen Cristescu, Mihaiela Andoni, Georgeta Maria Simu, Daniel Malita, Ioana Malita, Adelina Cheveresan
Endogenous and Exogenous Antioxidant Protection
for Endothelial Dysfunction

Abstract:

We performed „in vitro” experiments using human mammary artery rings, in order to examine the effect of endogenous and exogenous antioxidants on endothelial-dependent vasodilatation induced by cumulative doses (10-9 M - 10-4 M) of adenosine (ADP) and to study the effect on endothelial - independent vasodilatation induced by cumulative doses (10-9 M -10-4M) of sodium-nitroprusside (NSP), respectively. Our results showed that 1 hour pre-incubation with triglyceride diminished the endothelial-dependent vasodilator response to ADP, but it has not modified the endothelial -independent vasodilator response to NSP. Vascular response was expressed as maximal vasodilatation from the 10-5 M phenilephrine (PE) induced pre-contraction, considered as reference. One hour co-incubation of the rings with triglyceride and antioxidant factors, such as 10-3 M reduced glutathione (GSH) or 10-3 M ascorbic acid significantly reduced the impairment of the vasodilatation response to ADP (p = 0.02 for GSH, and p = 0.008 for ascorbic acid) but has not modified the vasodilatation response to NSP. As a conclusion, the endothelial dysfunction induced by the triglyceride could contribute to the pathogenesis of atherosclerosis and the treatment with high doses of antioxidants could „protect” the endothelium against the pro-atherogenic action of the triglyceride. Keywords: antioxidants, endothelial dysfunction, sodium nitroprusside

Issue: 2011, Volume 62, Issue 6

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