BOGDAN TITA, MIRCEA STEFANESCU, DUMITRU TITA<br>Complexes of the Anti-inflamatory Non-steroidal <br>Drugs from Oxicam Family<br>1. Synthesis and characterization of the Zn(II) complex with Piroxicam

BOGDAN TITA, MIRCEA STEFANESCU, DUMITRU TITA
Complexes of the Anti-inflamatory Non-steroidal
Drugs from Oxicam Family
1. Synthesis and characterization of the Zn(II) complex with Piroxicam

Abstract:

Zinc(II) complex of piroxicam with interesting anti-inflammatory profile has been prepared and characterized by elemental analysis, FT-IR spectroscopy, X-ray diffractometry and thermal analysis. The empirical formulae of the complex, [Zn(PX)2(H2O)2] x 2H2O was determined by the mentioned methods, but especially by elemental analysis and the thermoanalytical methods. From the FT-IR spectrum and X-ray diffractogram was established that the piroxicam, as ligand, binds to the Zn(II) ion monodentaly through their enolic oxygen and pyridinc nitrogen atom, respectively. The thermal behaviour of the complex was studied by simultaneous TG-DTG-DTA methods, under non-isothermal conditions and in a dynamic air atmosphere. According to the thermal curves, especially TG curve, the complex contain two molecules of co-ordination water and two molecules of crystallization water, respectively. On further heating of the anhydrous compound up to 807 °C the thermal degradation of the piroxicam and the intermediate formed took place. Zinc oxide was found as the final product of the thermal decomposition. Keywords: piroxicam, zinc(II) complex, elemental analysis, thermogravimetry, thermal decomposition

Issue: 2011, Volume 62, Issue 10

Pages:

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)