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REVISTA DE CHIMIE
Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
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Revista de Chimie (Rev. Chim.), Year 2012, Volume 63, Issue 1,





SANDU TARAS, ALEXANDRU WOINAROSCHY
Multi-objective Optimization of Citric Acid Bioprocess: A Modern Approach

Abstract:

The paper deals with multi-objective cost-environment optimization of bioprocesses. Citric acid is one of the most important organic acids produced by microbiological methods. Due to the fact that market is very competitive, the process economics is of paramount importance for survival. The optimization strategy can play an important role in reduction of production costs. The optimization approach consists in coupling a process simulator (i.e. SuperPro Designer) with a high-level numerical computing language (i.e. Matlab) in an optimization loop. The high-level language expands the simulator functionality by offering access to its optimization tools and the possibility of creating complex scripts (e.g. scripts for ecological evaluation of a bioprocess, mathematical models for unitary procedures etc.) which can be linked to the simulator. The aim of this strategy is to realize a complete multi-objective optimization by linking a dynamic model of the bioreactor elaborated in Matlab with a process model of the complete production plant implemented in SuperPro Designer. The obtained results show how the proposed methodology can be used to find a range of trade-off solutions for optimizing citric acid production bioprocess. Keywords: biochemical processes, citric acid, simulation, optimization

Issue: 2012, Volume 63, Issue 1
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