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https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
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Revista de Chimie (Rev. Chim.), Year 2012, Volume 63, Issue 5,





Alina Mihalcea, Camelia Ungureanu, Ana Aurelia Chirvase, Adrian Onu
Separation by Microfiltration of Rhodotorula Rubra
Cells from the Culture Broth

Abstract:

Torularhodin is one of the carotenoid pigments produced by the yeast Rhodotorula sp., with a terminal carboxylic group considered now-a-days as a powerful antioxidant to be included in food and drugs formulations. The paper describes the separation phase for the preparation of the torularhodin, obtained from the Rhodotorula rubra yeasts cells. At the end of the bioprocess, the cell mass was concentrated by cross-flow microfiltration. Rhodotorula rubra was grown in 10 L stirred tank bioreactor in the MS3 medium. The final research stage was to estimate the membrane surface of the microfiltration module needed to perform all the separation operations applied on biomass separation from the broth for a maximum duration of 3.5 h and for 42 L culture broth (pilot scale). Keywords: Rhodotorula rubra, torularhodin, microfiltration, membrane cleaning


Issue: 2012, Volume 63, Issue 5
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