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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2012, Volume 63, Issue 9,





CAMELIA PAPUC, MARIA CRIVINEANU, VALENTIN NICORESCU, CORINA PREDESCU
Reactive Oxygen Species Scavenging Activity and Hepatoprotective Effects of a Polyphenolic Extract Obtained from Cuscuta Europaea

Abstract:

The study intended to investigate reactive oxygen species scavenging ability and the hepatoprotective effect of a polyphenolic extract obtained from Cuscuta europaea in N-acetyl-p-aminophenol - induced liver injuries in rats. Chemiluminescence investigations showed that polyphenols extracted from Cuscuta europaea have a strong capacity to scavenge reactive oxygen species H2O2, 1O2, •OH, O2•] , and RCOO•. In vivo studies demonstrated that polyphenols extracted from Cuscuta europaea have a remarkable hepatoprotective potential. Thus, the administration of Cuscuta europaea polyphenols in liver injuries induced by N-acetyl-p-aminophenol in rats determined significant improvements in the levels of serum enzymes - markers of liver cytolysis, increased activity of the antioxidant enzymes, increased levels of liver glutathione and decreased levels of compounds that react with thiobarbituric acid in liver. Keywords: Cuscuta europaea; polyphenols, reactive oxygen species, hepatoprotective activity,antioxidant activity


Issue: 2012, Volume 63, Issue 9
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