Mihaela Violeta Ghica, Madalina Georgiana Albu, Cristina Dinu-PIrvu, Stefan Moisescu<br>In vitro Kinetic Release and Flow Behaviour of Some <br>Collagen-Minocycline Topical Hydrogels

Mihaela Violeta Ghica, Madalina Georgiana Albu, Cristina Dinu-PIrvu, Stefan Moisescu
In vitro Kinetic Release and Flow Behaviour of Some
Collagen-Minocycline Topical Hydrogels

Abstract:

The aim of this work was to develop some topical hydrogel based on collagen-minocycline uncross-linked and cross-linked with glutaraldehyde and to investigate its flow and kinetic behaviour. The rheological measurements were performed using a rotational viscometer. The release studies were conducted using a sandwich device adapted to paddle disolution apparatus. The tested hydrogels showed a pseudoplastic and shear thinning, and also a thixotropic behaviour. Different rheological descriptors were evaluated. The in vitro release data obtained were fitted according to different kinetic models and the highest value for the correlation coefficient was obtained for the power law model. The kinetic and flow properties are strongly influenced by the hydrogel compositions. The quantitative relantionships established between flow and release characteristics indicated a good correlation of these parameters. The results showed that the properties of designed hydrogels allow them to be used for the treatment of soft infected tissues. Keywords: hydrogel, collagen, minocycline, rheological descriptors, drug release

Issue: 2012, Volume 63, Issue 9

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