LIVIA PETRESCU, OTILIA CINTEZA, ANA-MARIA VOICULESCU, TUDOR ROSU, IONUT ENCULESCU, ELENA MATEI,SERBAN GEORGESCU, RUXANDRA BIRJEGA, SPERANTA AVRAM, DAN MIHAILESCU<br>Interaction of NaYF4:Er:Yb Nanoparticles with Phospholipid Monolayers as Models of Biological Membranes

LIVIA PETRESCU, OTILIA CINTEZA, ANA-MARIA VOICULESCU, TUDOR ROSU, IONUT ENCULESCU, ELENA MATEI,SERBAN GEORGESCU, RUXANDRA BIRJEGA, SPERANTA AVRAM, DAN MIHAILESCU
Interaction of NaYF4:Er:Yb Nanoparticles with Phospholipid Monolayers as Models of Biological Membranes

Abstract:

Given the evolution of imaging techniques in the biomedical field is becoming more necessary to develop sensitive markers, less toxic and not least more economical. Upconverting luminescent nanocrystals doped with rare earth ions, excited in infrared and emitting in visible, are considered real concurrent to classical fluorescent markers, featuring a number of advantages in rapport with them. The aim of this study is to prepare NaYF4 nanoparticles doped with erbium and ytterbium for biological applications in bioimaging techniques. After synthesis, upconverting nanoparticles were coated with SiO2 for surface sealing and passivation. The nanoparticles were characterized by X-ray diffraction, luminescence spectroscopy, electronic microscopy and dynamic light scattering. The interaction of the nanoparticles with mimicking cell membrane models was studied. NaYF4 nanoparticles showed a good size distribution and good emission efficiency. The uncoated nanoparticles increase the fluidity of the lipid monolayer, while the effect of the silica coated nanoparticles is substantially reduced. Keywords: up-conversion; NaYF4; biomarkers, biocompatibility; cell membrane models

Issue: 2012, Volume 63, Issue 9

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