Mircea TAMPA, Clara MATEI, Sanda POPESCU, Simona-Roxana GEORGESCU, Monica NEAGU, Carolina CONSTANTIN, Rodica-Mariana ION<br>Zinc Trisulphonated Phthalocyanine Used in Photodynamic <br>Therapy of Dysplastic Oral Keratinocytes

Mircea TAMPA, Clara MATEI, Sanda POPESCU, Simona-Roxana GEORGESCU, Monica NEAGU, Carolina CONSTANTIN, Rodica-Mariana ION
Zinc Trisulphonated Phthalocyanine Used in Photodynamic
Therapy of Dysplastic Oral Keratinocytes

Abstract:

Photodynamic therapy is an alternative antitumoral procedure that requires the use of a photosensitiser and a light source emitting radiation with an adequate wavelength, suitable for activating the photosensitiser; the most common photosensitisers are porphyrins and porphyrin-related substances. Phthalocyanines are macrocyclic chemical compounds structurally related to the porphyrins, as they both feature four linked pyrrole-like subunits, therefore possessing the potential of acting as good photosensitisers; metallo-substituted sulphonated phthalocyanines are novel chemical compounds that revealed promising results when used in PDT. Activated photosensitisers can lead to the destruction of the tumoral cells through production of reactive oxygen species and the induction of apoptosis. The present study aims to assess, via protein microarray analysis, the main molecular pathways involved in the apoptosis of dysplastic oral keratinocytes following photodynamic therapy using zinc tri-sulphonated phthalocyanine. Keywords: apoptosis, Zinc-trisulphonated phthalocyanine, photodynamic therapy

Issue: 2013, Volume 64, Issue 6

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