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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2013, Volume 64, Issue 6,





TACHITA Vlad-Bubulac, ANA - MARIA Oprea, DIANA Serbezeanu, IONELA - DANIELA Carja, CORNELIU Hamciuc
In vitro Release of Metoprolol Tartrate from Poly(vinyl Alcohol)/Phosphoester chondroitin Sulfate Semi-IPNs

Abstract:

The present work focuses on the analysis of some semi-interpenetrating polymer networks (semi-IPNs), based on phosphorylated poly(vinyl alcohol) (PVA) and chondroitin sulfat (CS), as sustained release carriers. The investigations were performed on poly(vinyl alcohol)/phosphoester - chondroitin sulfate semi-IPNs hydrogels (PVA/P-CS semi-IPNs) in various mixing ratios. Swelling and drug delivery studies were conducted in a phosphate buffer solution (pH = 7.4) that mimics the pH of the intestinal fluid, at 37 oC. The hydrogels were evaluated for the release of metoprolol tartrate. The release profiles of the drug from PVA/P-CS semi-IPNs were strictly dependent on the CS content: an increase in the percent of released drug was observed with increasing the CS content. Keywords: phosphorylated poly(vinyl alcohol), chondroitin sulfate, metoprolol tartrate, release kinetics


Issue: 2013, Volume 64, Issue 6
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