AURA LICSANDRU*, VERONICA NACEA, RICA BOSCENCU<br>Investigation of Uncertainty Contributions for Elemental Analysis <br>of Sesized Street Heroin by ICPMS

AURA LICSANDRU*, VERONICA NACEA, RICA BOSCENCU
Investigation of Uncertainty Contributions for Elemental Analysis
of Sesized Street Heroin by ICPMS

Abstract:

The aim of the study was the identification and quantification of uncertainty sources associated with heroin elemental analysis by Inductively Coupled Plasma Mass Spectrometry (ICP-MS) following sample dissolution through microwave assisted acid digestion. The percentage contribution of each source to the relative combined uncertainty was also calculated.The “bottom-up” approach was used to estimate the measurement uncertainty, while weighing of samples, analyte recovery, sample volume, calibration curve and repetability were considered for uncertainty sources. The range of expanded uncertainties was 5.71-14.87% (using a coverage factor k = 2, which gives a level of confidence of approximately 95%) for Al, Mg, Cu and Co concentration and obtained data indicate major contribution to the uncertainty budget originating from the calibration curve and also from the preparation of calibration standards. We found that the uncertainties caused by samples weighing, sample preparation and repeatability of ICP-MS measurement have no dominant contribution to the overall uncertainty and the uncertainty due to recovery was below 10%. Keywords: heroin, ICP-MS, Ishikawa Diagram, uncertainty sources, uncertainty budget

Issue: 2013, Volume 64, Issue 11

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