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Revista de Chimie (Rev. Chim.), Year 2013, Volume 64, Issue 12,





Bogdan Tita*, Eleonora Marian, Gerlinde Rusu, Geza Bandur, Dumitru Tita
Effects of Experimental Conditions on the Thermal Behaviour
of Some Non-steroidal Anti-inflammatory Drugs

Abstract:

Data on the thermal stability of drugs was required to obtain information for handling, storage, shelf life and usage. In this work, the thermal stability of four non-steroidal anti-inflammatory drugs (NSAIDs): Ibuprofen (IB), Ketoprofen (KT), Indomethacin (IND) and Piroxicam (PX) was determined by simultaneous thermogravimetery/differential thermal analysis (TG/DTG/DTA) techniques. The results of TG/DTG analysis show that the main thermal degradation for IB, KT, IND and PX occurs in the temperature ranges of 175-300°C ; 235-400°C ; 235-450°C respectively 200-450°C. The TG/DTA analysis of compounds mentioned show the following temperatures of melting: IB-78.5°C; KT-96.8°C; IND-162.7°C; respectively PX-200.3°C. Moreover, the influence of heating rate and sample size on the thermal decomposition of examined compounds was evaluated. The results show that the increase of two parameters has influence on the temperature range and the shape of thermoanalytical curves, especially the heating rate. Keywords: thermal behaviour, ibuprofen, ketoprofen, indomethacin, piroxicam, NSAIDs, TG/DTG/DTA


Issue: 2013, Volume 64, Issue 12
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