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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2013, Volume 64, Issue 12,





Dorin Manciula*, Carmen Roba, Ioan Oprean, Radu MiSca-Barbu
Synthesis of Ursolic Acid Dipeptide Derivates
with Potential Biological Activity

Abstract:

Ursolic acid is a natural compound, a pentacyclic triterpene, found in abundance in many species of native wild flora. The experimental study was intended to extract ursolic acid from Calluna vulgaris, L. Hull, (Ericaceae) and its derivatization to obtain dipeptide compounds with potential biological activity. For this purpose, three dipeptides were used: alanyl-glycine, glycyl-leucine and leucyl-glycine. The biological activity of ursoloil-glycyl-leucine has been tested on several cancer cells lines, A2780, A431, HeLa and MCF-7. Keywords: ursolic acid, dipeptides, biological activity

Issue: 2013, Volume 64, Issue 12
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