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Revista de Chimie (Rev. Chim.), Year 2014, Volume 65, Issue 4,





GABRIELA MARINESCU, DANIELA C. CULITA, LUMINITA PATRON, SULTANA NITA, LUMINITA MARUTESCU, NICOLAE STANICA, OVIDIU OPREA
Synthesis, Characterization and Antimicrobial Evaluation of Lanthanide(III) Complexes with Meloxicam

Abstract:

Three new complexes of lanthanides (La, Pr, Nd) with meloxicam as ligand of the type Ln2(HMel)2(CH3COO)4·H2O were synthesized. The formula of complexes have been assigned from elemental chemical analysis, IR, UV-Vis-NIR, TG/DSC, magnetic and conductivity data. In all complexes meloxicam acts as bidentate ligand coordinating to the metal ions through the nitrogen atom of the thiazole ring and amidic oxygen atom. All complexes and meloxicam were screened for their antimicrobial activity against 7 microbial strains: Enterococcus faecium E5, Escherichia coli ATCC 25922, Candida albicans 1760, Pseudomonas aeruginosa ATCC 27857, Bacillus subtillis ATCC 6683, Staphylococcus aureus ATCC 6538, Klebsiella pneumoniae IC 13420. The ability of compounds to inhibit the microbial adherence ability to the inert substratum was also evaluated. The results demonstrated that some of the tested compounds exhibit very good antimicrobial and antibiofim activity. Keywords: meloxicam, lanthanides, coordination compounds, antimicrobial activity


Issue: 2014, Volume 65, Issue 4
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