Loredana FILIP, Ioan-Avram NEDELCU, Camelia UNGUREANU, Maria SONMEZ, Ecaterina ANDRONESCU<br>Methylene Blue based Antiseptic Chitosan/hydroxyapatite Composite Materials

Loredana FILIP, Ioan-Avram NEDELCU, Camelia UNGUREANU, Maria SONMEZ, Ecaterina ANDRONESCU
Methylene Blue based Antiseptic Chitosan/hydroxyapatite Composite Materials

Abstract:

Bone graft materials based on chitosan and hydroxyapatite were obtained. The materials were characterized by XRD, FTIR spectroscopy and microscopy and SEM microscopy. Based on XRD, pure HA has been obtained while FTIR analyses confirm the formation of the desired composite materials, and in the case of chitosan/hydroxyapatite/methylene blue composite materials, even the presence of methylene blue can be proved. Based on the FTIR microscopy it seems that methylene blue is preferentially distributed onto the hydroxyapatite. The antibacterial activity was tested against E. coli and prove that chitosan induce antibacterial effect while the addition of methylene blue further improve this activity. The precipitation conditions of hydroxyapatite were similar with those used for the preparation of collagen and hydroxyapatite composite materials. Consequently, the method can be further used in case of the synthesis of more complex antiseptic composite materials containing both collagen and chitosan, the antiseptic properties of the composite being tailored by the proper choosing of chitosan:methylene blue ratio. Keywords: chitosan/hydroxyapatite composite material, antiseptic bone grafts, infrared microscopy

Issue: 2014, Volume 65, Issue 5

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