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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2014, Volume 65, Issue 5,





Tamer E. Youssef, Yahia A. Alhamed, Saad S. Al-Shahrani, Korany A. AliAntitumor Activity of Tetra-Substituted Zinc Phthalocyanines Containing 4(3H)-Quinazolinone Derivatives

Abstract:

Series of tetra-substituted zinc(II)phthalocyanines (ZnPcs) bearing four 4(3H) quinazolinone ring system units (qz)4ZnPcs 4a-c have been synthesized and characterized. They were screened for their in-vitro antitumor activity on Human lung adenocarcinoma (A549), human breast adenocarcinoma (MCF-7) and Hepatocellular carcinoma (HEPG2). Preliminary study of the structure-activity relationship showed that electronic factors in the 4(3H)-quinazolinone moiety that attached to the ZnPc skeleton had a magnificent effect on the antitumor activity of the newly synthesized (qz)4ZnPcs 4a-c. They showed promising anticancer activity against the tested human cancer cell lines. The detailed synthesis, characterization and biological screening data were reported. Keywords: 4(3H)-quinazolinone, zinc(II)phthalocyanines, hetero-substituted phthalocyanines, anticancer activity, biological targeting agents


Issue: 2014, Volume 65, Issue 5
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