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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2014, Volume 65, Issue 6,





Tudor Olariu, Lenuta-Maria Suta, CAlin Popoiu, Ionut VALENTIN Ledeti1c, Georgeta MARIA Simu1c, Germaine Savoiu - BALINT, Adriana Fulias1c
Alternative Synthesis of Paracetamol and Aspirin under
Non-conventional Conditions

Abstract:

The paper deals with an alternative route for the synthesis of N-acetyl-p-aminophenol (paracetamol, PAR) and acetylsalicylic acid (aspirin, ASA) using principles of green chemistry, namely solvent-free synthesis combined with microwave-energy irradiation. The synthesis was carried out using salicylic acid and 4-aminophenol, acetic anhydride and no catalyst, under microwave irradiation. The yields were 92.4% for PAR and 81.6% for ASA. The compounds were identified by comparison with high-purity standards by the means of thin layer chromatography (TLC), melting point (m.p.) and FTIR spectroscopy. Keywords: paracetamol, aspirin, microwave irradiation, green chemistry, synthesis


Issue: 2014, Volume 65, Issue 6
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