GEORGETA MARIA SIMU, IONUT VALENTIN LEDETI, SIMONA GABRIELA MUNTEAN, ADRIANA FULIAS, IOANA MIHAELA CITU, CODRUTA SOICA, DOINA ONISEI, GERMAINE SAVOIU - BALINT, IULIA PINZARU, DANIELA IONESCU<br>Study of the Interaction of Some Pharmaceutical Compounds <br>with Different Cellulosic Supports

GEORGETA MARIA SIMU, IONUT VALENTIN LEDETI, SIMONA GABRIELA MUNTEAN, ADRIANA FULIAS, IOANA MIHAELA CITU, CODRUTA SOICA, DOINA ONISEI, GERMAINE SAVOIU - BALINT, IULIA PINZARU, DANIELA IONESCU
Study of the Interaction of Some Pharmaceutical Compounds
with Different Cellulosic Supports

Abstract:

The interaction of two pharmaceutical compounds (aspirin and diclofenac) on some cellulosic type supports (cotton fibre, microcrystalline cellulose and fir wood) has been investigated in order to establish in the case of each system the best theoretical adsorption model, as well as their characteristic thermodynamic parameters (enthalpy and entropy). The adsorption process of the pharmaceutical compounds onto the mentioned cellulosic supports was studied by means of spectrophotometry, at three different temperatures (298 K, 308 K and 318 K). The preliminary experiments indicated that absorption equilibrium was attained in a period of time ranging from 150 to 450 minutes, in the case of the investigated systems. The experimental results were fitted to some classical adsorption models such as Freundlich and Langmuir, as well as to some untested ones for these systems type, namely Sips and Jossens isotherm models. The statistical analysis of the obtained results indicated that in all cases, the Sips model described better the adsorption of the model compounds on the investigated supports by comparison to the classical models, as well as to the Jossens’ one. Keywords: pharmaceutic compounds, adsorption isotherms, cellulosic supports

Issue: 2014, Volume 65, Issue 6

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