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Revista de Chimie (Rev. Chim.), Year 2014, Volume 65, Issue 6,





Alin Bors, Gabriela Niculae, Raluca Stan*, Aurelia Meghea
Lipid Nanocarriers with Antifungal Activity Prepared by
High Pressure Homogenization

Abstract:

Nanostructured lipid carriers (NLC) are promising nanoparticulate delivery systems produced from blends of liquid and solid lipids. In the present paper, the influence of different synthesis parameters (e.g. pressure, homogenization cycle, surfactant and drug concentrations, lipid blends etc.) on the main particles diameters of Nystatin-loaded NLC prepared by high pressure homogenization method have been monitored by dynamic light scattering technique. NLC formulations were prepared using two different lipid mixtures (Emulgade, Glycerol monostearate and Savory oil) and using two surfactants systems as stabilizing agents. Dynamic light scattering measurements performed on NLC showed that the oil nanocompartments incorporated into NLC solid matrix provide a good distribution of the antifungal agent inside the nanocarrier system. The percentage of encapsulated Nystatin is influenced by the concentration of Savory oil and lipid blend. From the results obtained, the prepared lipid nanocarriers showed an increase of Nystatin entrapment for 1% loading in comparison with 0.5% loading. Chemiluminescence assay proved that the protective activity against oxygen free radicals has been increased by incorporation of Savory oil into lipid nanocarriers. Keywords: lipid nanocarriers, nystatin, high pressure homogenization


Issue: 2014, Volume 65, Issue 6
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