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Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
ISSN Online 2668-8212
ISSN Print: 1582-9049
ISSN-L: 1582-9049

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Revista de Chimie (Rev. Chim.), Year 2014, Volume 65, Issue 7,





Ramona-Daniela Pavaloiu, Anicuta Stoica-Guzun, Marta Stroescu, Tanase Dobre
Use of Bacterial Cellulose as Reinforcement Agent and
as Coating Agent in Drug Release Applications

Abstract:

In this study the use of bacterial cellulose (BC), a biopolymer with remarkable features, as reinforcement agent and as coating agent for drug release applications was investigated. Therefore, poly(vinyl alcohol)-chitosan blends, containing ibuprofen sodium salt as model drug, reinforced with various amounts of BC fibrils uncoated and coated with BC layers were prepared and characterized by FT-IR and SEM. Swelling and drug release studies were performed at pH 1.2 and 7.4. Results revealed that the incorporation of BC fibrils as reinforcement agent affects both swelling and drug release and by its content variation a desirable swelling values and release rates could be obtained. Also, it was observed that coating with BC sheets minimize burst release and provides lower drug release rates. All data suggest that BC is a promising material for drug delivery applications. Keywords: poli(vinyl alcohol), chitosan, bacterial cellulose, drug release, ibuprofen sodium salt


Issue: 2014, Volume 65, Issue 7
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