Laura Cristina Rusu, Eliza Seche, Paul Cornel Freiman, Bogdan Hoinoiu,MeDa Lavinia Negrutiu,Lavinia Ardelean, Cosmin Sinescu<br>Synchrotron Radiation X-Ray micro-CT evaluation <br>of Bone Augmentation

Laura Cristina Rusu, Eliza Seche, Paul Cornel Freiman, Bogdan Hoinoiu,MeDa Lavinia Negrutiu,Lavinia Ardelean, Cosmin Sinescu
Synchrotron Radiation X-Ray micro-CT evaluation
of Bone Augmentation

Abstract:

The osteoconductive and regenerative materials are very important in bone regeneration process. We propose in this study to evaluate the interface between the old and the new regenerated bone. 60 rats femurs were used for this investigation. Under strict supervision, the holes were drilled in the rat femurs and then the entire defect is filled with different bone augmentation materials in order to promote the proliferation of neoformating bone. The samples were obtained after animals are x-rayed using dental equipment for evaluation of the healing process at 2, 4, 6, 8, 10, and 12 weeks, aiming to reveal the influence on the site of bone defect, reaction in the area, vascular reaction and radiopaque changes. A synchrotron radiation X-Ray micro-CT experiment was performed at the SYRMEP Beamline of the ELETTRA Synchrotron Radiation Facility (Trieste, Italy). The 1200 radiographic projections were acquired with a beam energy of 29 keV over 180° with a pixel size of 9 µm. A sample - detector distance of 15 cm was considered in order to have both absorption and phase-contrast signal, for a better viewing of the interfaces. For 3D visualization, data volumes were rendered directly without decomposing them into geometric primitives. A commercial software - VGStudio MAX - was used to generate 3D images and to visualize the distribution in 3D of different constituents. Keywords: healing proces, bone defect, X-Ray micro-CT

Issue: 2014, Volume 65, Issue 9

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