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Revista de Chimie (Rev. Chim.), Year 2014, Volume 65, Issue 11,





Anca Mihaela Mocanu, Constantin Luca, Simona Isabela Dunca, Gabriela Ciobanu
Antibacterial Activity of Some New Hydrazide Derivatives
with Potential Biological Action

Abstract:

In the present paper the results of some studies on the synthesis of some new derivatives of sulfonamidated aryloxyalkylcarboxylic acids obtained by the condensation of their hydrazides with several substrata affording final compounds with potential biological activities such as anti-tumour, anti-oxidative, anti-tubercular as well as fungide, acaricide and plant growth regulating actions are reported. The synthesis stages of the new products (azomethines and diazoaminoderivatives) are presented as well as the elemental analysis data and IR, 1H-NMR spectral measurements aimed to elucidate the chemical structures while the anti-microbial properties were confirmed by microbiological tests. The anti-microbial activity was estimated by measuring the growth inhibition area for four different strains of microorganisms: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. The tests performed have confirmed the potential biological properties of the newly obtained compounds. Keywords: azomethines, diazoaminoderivatives, IR, 1H-NMR spectra, antimicrobial activity


Issue: 2014, Volume 65, Issue 11
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