ABOUT INDEXING BOARD ARCHIVES AUTHOR GUIDELINES SUBMIT PAPER AUTHOR'S PAGE NEWS, EVENTS CONTACT
REVISTA DE CHIMIE
Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
ISSN Online 2668-8212
ISSN Print: 1582-9049
ISSN-L: 1582-9049

REVISTA DE CHIMIE Latest Issue

LATEST ISSUE >>>

   Volume 75, 2024
   Volume 74, 2023
   Volume 73, 2022
   Volume 72, 2021
   Volume 71, 2020
   Volume 70, 2019
   Volume 69, 2018
   Volume 68, 2017
   Volume 67, 2016
   Volume 66, 2015
   Volume 65, 2014
   Volume 64, 2013
   Volume 63, 2012
   Volume 62, 2011
   Volume 61, 2010
   Volume 60, 2009
   Volume 59, 2008
   Volume 58, 2007
 
<<<< back

Revista de Chimie (Rev. Chim.), Year 2015, Volume 66, Issue 1,





EMRE MENTESE, OLCAY BEKIRCAN, FATIH ISLAMOGLU, FATIH SABAN BERIS
Microwave Assisted Synthesis of Some Novel
2-(3-Chlorobenzyl)-1H-Benzimidazole Derivatives
and Determination of Their Antimicrobial Activity and pKa Values

Abstract:

In the present research, synthesis of new 2-(3-chlorobenzyl)-1H-benzimidazole derivatives bearing N-benzylidene, 1,2,4-triazole and N-acylhydrazone moiety is investigated. These novel compounds have been tested for their antimicrobial effects against two of Gram-positive bacterial strains, namely Bacillus subtilis and Staphylococcus epidermidis, and four Gram-negative bacterial strains which were Enterobactercloaceae, Klebsiellapneumonie, Proteus vulgaris, and Salmonella typhymirium. According to their MIC values, which reflect their activity on the bacteria, were classified in three grops: best, good and moderate. So, the best MIC values were obtained 6a and 6b. On the other hand, the acidity values of pKa for 6a-d derivatives were calculated with MOPAC 2012 computer program using physico-chemical semi-empirical methods (AM1, MNDO, MNDOD, PM3, PM6, PM6-DH2, PM7 and RM1) in water, ethyl alcohol, methyl alcohol, n-propyl alcohol, isopropyl akcohol, n-butyl alcohol, tert-butyl alcohol, ethylene glycol, N,N-dimethyl formamide, N,N-dimetyl sulfoxide and acetonitrile at 25oC. Keywords:benzimidazoles, hydrazinecarbothioamides, 1,2,4-triazoles, N-acylhydrazones, antimicrobial activity, pKa and MOPAC 2012 computer program

Issue: 2015, Volume 66, Issue 1
Pages:
download pdf   Download Pdf Article
Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
 
<<<< back
 
PUBLISHING SECTION
Author Guidelines
 * Paper Drafting
 * Paper Template
 * Ethical Statement
 * Paper Submission
Ghidul Autorului (ro)
Submit Paper
Author's Page
Publishing Ethics
Peer Review Process
Open Access & Archiving Policy
 Search Authors
 LATEST NEWS
REvista de Chimie NUMAR OMAGIAL PETRU PONI.. detalii
REvista de Chimie Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
dictionar English-Romanian Dictionary for Mechanical Engineering
(download pdf)
  News, Events
Crossref Member Badge
 DOI  logo
 Gold Open Access | Source=http://www.plos.org/  | Author=art designer at PLoS
Creative Commons License
 Conferences of Contemporary
 Chemistry
 Biblioteca Chimiei
 Materiale Plastice