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REVISTA DE CHIMIE
Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
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Revista de Chimie (Rev. Chim.), Year 2015, Volume 66, Issue 1,





IOANA MIHAELA CITU, FLORIN BORCAN, CSILLA ZAMBORI, BOGDAN TITA, VIRGIL PAUNESCU, SIMONA ARDELEAN
Influence of Crosslinking Agent - Chain Extender Ratio
on the Properties of Hyperbranched Polyurethane Structures
used as Dendritic Drug Carrier

Abstract:

Polyurethanes (PU) are versatile chemical compounds with vastly differing biological and mechanical properties. The slight possibility of converting their properties allow them to be used in many applications, particularly for the biomedical and pharmaceutical fields. In this study, lysine diisocyanate ester (LDI), tris(hydroxymethyl)aminomethane (THAM), 1,4-butanediol (BD) and polyethylene glycol (PEG) were used to obtain hyperbranched PU structures. There were studied the size and stability of the PU structures and the thermal behavior of samples. In vitro assays on cells culture were used to observe the cytotoxic potential of obtained products. The sizes and stability of the obtained PU structures and the absence of any cytotoxic potential recommend their usage as drug delivery system. Keywords: polyurethane, drug-delivery system, cytotoxic potential, zeta potential

Issue: 2015, Volume 66, Issue 1
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