BOGDAN I. TAMBA, TUDOR PETREUS, MARIA-MAGDALENA LEON CONSTANTIN*, CIPRIAN REZUS*, MARIANA FLORIA, ELENA REZUS<br>Heavy Metal Trace Elements Induced Antinociception in an Experimental Mouse Model

BOGDAN I. TAMBA, TUDOR PETREUS, MARIA-MAGDALENA LEON CONSTANTIN, CIPRIAN REZUS, MARIANA FLORIA, ELENA REZUS
Heavy Metal Trace Elements Induced Antinociception in an Experimental Mouse Model

Abstract:

Heavy metal trace elements (HMTE) represent a group of metals or metalloids, present in minute amounts in humans but also frequently present in various dietary supplements on the market, including those for pain therapy. Cobalt (Co), Nickel (Ni) or Molybdenum (Mo) are mostly associated with toxic effects. Previous in vitro studies on heavy metals and nociception and their potential influence on pain treatment have yielded limited results, with very few in vivo data available. We hypothesized that Co, Ni and Mo have direct in vivo antinociceptive effects. Swiss mice were intraperitoneally (i.p) injected with incremental doses of Co and Ni chlorides, sodium Mo or saline and evaluated by hot plate (HP) and tail flick (TF) tests for central antinociceptive effect, writhing test (WT) for visceral antinociceptive effect and activity cage (AC) test for spontaneous behaviour. Co induced a dose dependent pain inhibition in HP/TF tests (30.87%/16.64%) and WT (100%/77.23%). Ni and Mo salts showed dose dependent anti-nociceptive effects for HP/TF (20.41%/13.4%) and WT (67.41%/67.86%). Only Co and Mo salts have displayed significant effects in AC (Co anxiolytic/depressant; Mo sedative). All tested metals induced various degrees of anti-nociceptive effects, especially in visceral pain tests, supporting HMTE as an important nociception investigation target. More importantly our results make a step forward in the investigation of how these trace elements may influence the traditional drug therapy in patients experiencing pain, when administered as daily food intake or dietary supplements. Keywords: nickel; molybdenum; cobalt; pain; dietary supplements

Issue: 2015, Volume 66, Issue 7

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This article is published under the Creative Commons Attribution 4.0 International License

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