Daniela Lucia Muntean, Gabriel Hancu, Hajnal Kelemen, Aura Rusu, Adriana Ciurba<br>Cyclodextrine Screening for the Chiral Separation of <br>Beta-blocker Derivatives

Daniela Lucia Muntean, Gabriel Hancu, Hajnal Kelemen, Aura Rusu, Adriana Ciurba
Cyclodextrine Screening for the Chiral Separation of
Beta-blocker Derivatives

Abstract:

The enantiomeric separation of nine frequently used b-blocker derivatives (atenolol, bisoprolol, carvedilol, labetalol, metoprolol, oxprenolol, pindolol, propranolol, sotalol) has been studied by capillary zone electrophoresis (CZE) using cyclodextrines (CDs) as chiral selectors directly added to the background electrolyte with the aim to establish the optimum experimental conditions for their chiral discrimination. Various native (a, b and g-CD), alkylated (hydroxypropyl-b-CD and randomly methylated-b-CD) and anionic (carboximethyl-b-CD and sulfobuthylether-b-CD) CD derivatives were tested and electrophorectic parameters such as buffer composition, concentration and pH as well as CD type and concentration were investigated. All the studied b-blockers showed significant stereoselective interactions with one particular or with several CD derivatives. The results of the study underline the most important role of the differences in the physico-chemical and structural characteristics of the b-blockers derivatives while interacting with inclusion compounds. Keywords: b-blocker derivatives, capillary electrophoresis, chiral separation, cyclodextrines,stereoselective interactions

Issue: 2015, Volume 66, Issue 7

Pages:

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)