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Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
ISSN Online 2668-8212
ISSN Print: 1582-9049
ISSN-L: 1582-9049

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Revista de Chimie (Rev. Chim.), Year 2015, Volume 66, Issue 7,





IOANA-CEZARA GRIGORIU, BOGDAN- IONEL CIOROIU, ANCA-MONICA STRUGARU, LUMINITA AGOROAEI, CRISTINA DEHELEAN, DANA STOIAN, ELENA BUTNARU
Preliminary Impurity Profile Study of Desloratadine
Used in Toxicological Studies

Abstract:

Desloratadine is a potent and selective peripheral H1 receptor antagonist, a major active metabolite of loratadine, used in treatment of allergic symptoms. The aim of this study was to identify and analyse the impurity profile of desloratadine used for quantitative determination in biological fluids by performant chromatographic methods. Materials and methods: Fourier transform infrared (FT-IR) spectrum of desloratadine was recorded using a Tensor 27 Opitcs FT-IR spectrophotometer. The method for related substances was performed using System HPLC Agilent 1100. Chromatographic profile was recorded using a ChemStation software. Validation parameters considered in order to assess preliminary method performance were linearity, precision, specificity. The study was able to verify the purity profile of desloratadine used in toxicological studies. Keywords: desloratadine, FT-IR spectroscopy, HPLC


Issue: 2015, Volume 66, Issue 7
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