Felicia Ciulu - Costinescu, Mariana Carmen Chifiriuc, Marcela Popa, Coralia Bleotu, Johny NeamTu, Larisa Marina Elisabeth Averis, Maria Viorica Bubulica, Andreea Simionescu, Ioana MAdAlina Aldea, Ionela Belu<br>Screening of Polyphenol Content and In vitro Studies <br>of Antioxidant, Antibacterial and Cytotoxic Activities of Capsicum Annuum Extracts

Felicia Ciulu - Costinescu, Mariana Carmen Chifiriuc, Marcela Popa, Coralia Bleotu, Johny NeamTu, Larisa Marina Elisabeth Averis, Maria Viorica Bubulica, Andreea Simionescu, Ioana MAdAlina Aldea, Ionela Belu
Screening of Polyphenol Content and In vitro Studies
of Antioxidant, Antibacterial and Cytotoxic Activities of Capsicum Annuum Extracts

Abstract:

In this study the polyphenolic profile of Capsicum annuum extracts was established by a RP-HPLC method. 11 acids derived from hydroxycinnamic acid and five flavonoids were quantified. The ellagic acid was present in high concentrations in all tested samples. The C. annuum extracts were also investigated for their antioxidant, antimicrobial and cytotoxic properties. In conclusion, the results of this study reveal that Capsicum annuum alcoholic extracts exhibit significant antioxidant properties, the highest antioxidant activity being obtained for the the green pepper extract (723.795 mg/L GAE, 3.315 mg/L trolox equivalents and 327.394 mg/L QE). Moreover, the antibacterial activity of the tested extracts was significantly higher as compared to the capsaicin standard used as positive control towards Enterococcus faecalis, E. coli and Bacillus subtilis strains and similar to capsaicin for Staphylococcus aureus strain. The results of the in vitro cytotoxicity assay revealed that the tested extracts revealed a good biocompatibility and did not alter the morphology of HACAT cells. Taken together, these biological properties indicate the potential of the obtained extracts to be used in different biomedical applications, as anti-rheumatic, anti-inflammatory and antimicrobial agents. Keywords: polyphenolic profile, RP-HPLC, ultrasonication extraction, Capsicum annuum L., antioxidant, antimicrobial, cytotoxicity

Issue: 2015, Volume 66, Issue 9

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This article is published under the Creative Commons Attribution 4.0 International License

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