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Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
ISSN Online 2668-8212
ISSN Print: 1582-9049
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Revista de Chimie (Rev. Chim.), Year 2015, Volume 66, Issue 9,





ANCA-MONICA STRUGARU, CORNELIA MIRCEA, LUMINITA AGOROAEI, GINA BOTNARIU, IOANA-CEZARA GRIGORIU, EODORA DANIELA MARTI, ELENA BUTNARU
Quantitative Determination of Metformin by Capillary
Electrophoresis with UV Detection

Abstract:

Capillary electrophoresis with UV detection is a simple modern method which can be used for the quantitative determination of many drugs. This study aims to develop and validate a method for the quantitative determination of metformin by capillary electrophoresis with UV detection. Electrophoretic separation was performed at pH=4.0, voltage +15.0 kV, after sample injection for 3 seconds at a pressure of 0.5 psi. UV detection was done at 200 nm. The following validation parameters were determined: linearity (r = 0.9999), limit of detection (LD) = 13.933 µg/mL, limit of quantification (LQ) = 42.223 µg/mL, precision (RSD = 3.83%) and accuracy (average recovery 100.50%). The validation results will allow the use of the method for metformin assay in biological fluids. Keywords: metformin, capillary electrophoresis, validation


Issue: 2015, Volume 66, Issue 9
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