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Revista de Chimie (Rev. Chim.), Year 2015, Volume 66, Issue 9,





NELA BIBIRE, MADALINA VIERIU, ALINA DIANA PANAINTE,LUMINITA AGOROAEI,LIVIA UNCU, CRISTINA VICTORINA VLASE,AUREL VLASE
A New High Performance Liquid Chromatographic Analysis
Method for Ciprofloxacin

Abstract:

A rapid and simple high performance liquid chromatographic method for the quantitative analysis of ciprofloxacin has been developed and validated. The separation was performed on an Agilent 1100 system equipped with a Zorbax XDB-CN (100mm x 4.6mm) column using a mobile phase consisting of a mixture of phosphoric acid solution and acetonitrile (90:10, v/v), at a flow rate of 0.8mL/min. The sample volume injected was 5mL. The retention time for ciprofloxacin was 1.8 min and the overall time of the analysis was 2.2 min. The detection was done spectrophotometrically at 278nm. The limit of quantification was 0.28 mg/mL. Calibration graphs were linear for 0.28-0.70mg/mL of ciprofloxacin, with a correlation coefficient of 0.998. The average recoveries for ciprofloxacin and coefficients of variation were 99.31% and 1.30% respectively. The new method was sensitive, specific and reproducible, suitable for the quantitative analysis of ciprofloxacin in various pharmaceuticals products. Keywords: ciprofloxacin, liquid chromatography, validation


Issue: 2015, Volume 66, Issue 9
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