ADRIAN STURZA, OANA DUICU, ADRIAN VADUVA, LAVINIA NOVEANU, MARIA DANILA, ANDREEA PRIVISTIRESCU, ROMULUS TIMAR, DANINA MUNTEAN, MIRCEA MUNTEANU<br>Reduction of Rage Expression by Vitamin D in Isolated Diabetic Rat Aortas

ADRIAN STURZA, OANA DUICU, ADRIAN VADUVA, LAVINIA NOVEANU, MARIA DANILA, ANDREEA PRIVISTIRESCU, ROMULUS TIMAR, DANINA MUNTEAN, MIRCEA MUNTEANU
Reduction of Rage Expression by Vitamin D in Isolated Diabetic Rat Aortas

Abstract:

High blood glucose level and advanced glycation end-products (AGE) are the major contributors to the development of vascular complications in diabetes mellitus. The receptors for advanced glycation end-products (RAGE) are upregulated in response to high blood glucose level and may play a role in the occurrence of diabetic-related vascular disease. Vitamin D is widely reported as a cardiovascular protective agent. The present study assessed the effects of 1,25-dihydroxycholecalciferol (1,25-VitD3) on the endothelial dependent relaxation (EDR) in organ bath studies and on vascular expression of RAGE by immunohistochemistry studies in aortic samples isolated from rats with experimental diabetes (streptozotocin, 50 mg/kg, single dose). Our findings indicate that: i) in diabetic aortas the EDR was significantly impaired (vs. control) together with a high expression of RAGE in the entire structure of the aortic wall and, ii) ex vivo treatment with 1,25-VitD3 (0.1 mM) significantly improved the relaxation response and reduced the aortic expression of RAGE in diabetic vascular samples. In conclusion, low amounts of vitamin D exerts beneficial effects on endothelial function in vitro; in particular, we firstly demonstrated the modulation of RAGE expression in the settings of experimental diabetes. Investigations aimed at elucidating the underlying signal transduction pathways are clearly warranted view the potential therapeutic effect. Keywords: vitamin D, diabetes mellitus, receptor for advanced glycation products

Issue: 2015, Volume 66, Issue 9

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