TUDOR PETREUS, ANA MARIA HOLICOV, LUCIAN BARBU TUDORAN, GHEORGHE GH. BALAN, DANA ELENA MITRICA<br>Synthesis and Biocompatibility Evaluation for a Phosphorylated Polyvinyl Alcohol Derivative

TUDOR PETREUS, ANA MARIA HOLICOV, LUCIAN BARBU TUDORAN, GHEORGHE GH. BALAN, DANA ELENA MITRICA
Synthesis and Biocompatibility Evaluation for a Phosphorylated Polyvinyl Alcohol Derivative

Abstract:

Polyvinyl alcohol and phosphorylated functionalized derivatives are widely used in tissue engineering and regenerative medicine. The present work aims to characterize chemically and biologically two types of samples based on phosphorylated polyvinyl alcohol. Synthesis and biocompatibility assays for a porous polymer scaffold based on PPVA reticulated by glutaraldehyde and foamed by CaCO3 in different ratios are shown above. Swelling index for the PPVA hydrogel goes up with the decrease in reticulation agent that has been used (glutaraldehyde) for foam production. A minimal recorded pH shift had no influence for the further development of in vitro cell assays. Moreover, samples immersed into SBF for 48h maintained their mechanical stability. Contact inhibition assay and imaging performed for 72 hours demonstrated a good cell proliferation in contact with the material sponge-like samples. Osteoblast-like cells recorded important viability in contact with both type of foam samples. The proposed PPVA-CaCO3 composite mainly conditioned as a foam represent a cheap and feasible solution for a biocompatible osteoconductive porous scaffold destined to tissue engineering. Keywords: polyvinyl alcohol, hydrogel, phosphorylation, porous polymer scaffold, osteoblast-like cell

Issue: 2015, Volume 66, Issue 11

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