MIRJANA POPOVSKA, VERA RADOJKOVA-NIKOLOVSKA, ANA MINOVSKA, DORIANA AGOP FORNA, ILIJANA MURATOVSKA, NORINA CONSUELA FORNA<br>Etiopathogenetic Biochemical Mechanism Involved <br>in Oral  Lichen Planus

MIRJANA POPOVSKA, VERA RADOJKOVA-NIKOLOVSKA, ANA MINOVSKA, DORIANA AGOP FORNA, ILIJANA MURATOVSKA, NORINA CONSUELA FORNA
Etiopathogenetic Biochemical Mechanism Involved
in Oral Lichen Planus

Abstract:

Although modern science and medicine have clinical, histological, histochemical and biochemical test methods, the etiology of oral lichen planus is still relatively unknown. Recent literature supports the theory that the disease is associated with reactions that still cannot be completely defined, but began as a cellular immune response. A total of 56 patients with oral lichen planus were examined, who formed the experimental group and 50 healthy people who formed the control group. Participants of the experimental group according to clinical manifestations are divided into three subgroups: reticular, erythema - exudative and bullous form. Both groups, control and experimental, were assessed for values of T and B lymphocytes in the blood. The tests are conducted twice, in a phase of exacerbation and remission. In the phase of exacerbation in all three clinical forms of oral lichen planus, T and B cells in peripheral blood are with evident increased percentage versus the control group, resulting in high statistical significance (p [ 0.001). In the phase of remission in reticular, erythema-exudative and bullous form has a decrease in the values of T and B cells which is still above control values and gives high significance (p [ 0.001), except for B lymphocytes in the reticular form where p [ 0.01. The increased values of T and B lymphocytes in the phase of exacerbation and remission can be explained by the chronicity of the process, which leads us to the conclusion that the immune system is reconstructed in terms of increased cell activity. Keywords: oral lichen planus, reticular, lymphocytes, peripheral blood, biochemical mechanism

Issue: 2015, Volume 66, Issue 11

Pages:

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)