LAURA CORINA NICOLESCU, BOGDAN TITA, TUNDE JURCA, ELEONORA MARIAN, DUMITRU TITA<br>Thermal Stability of Piroxicam - Active Substance and Tablets<br>I. Kinetic study of the active substance under non-isothermal conditions

LAURA CORINA NICOLESCU, BOGDAN TITA, TUNDE JURCA, ELEONORA MARIAN, DUMITRU TITA
Thermal Stability of Piroxicam - Active Substance and Tablets
I. Kinetic study of the active substance under non-isothermal conditions

Abstract:

The thermal methods of analysis are widely employed in the study of stability and thermal decomposition of substances used in medicine, especially drugs. Kinetic studies have become a crucial point in thermal analysis, having as main purpose to determine the kinetic model of thermal decomposition and to calculate the parameters of the Arrhenius equation. The present work reports the study of thermal behaviour of piroxicam active substance and tablets, based on the thermoanalytical curves, respectively the determination of the kinetic parameters. The kinetic study regarding the piroxicam - active substance’s thermal decomposition was performed under non-isothermal conditions, in a nitrogen atmosphere, at five heating rates: 2.5; 5; 7.5; 10 and 15°C/min. The kinetic parameters of thermal decomposition process were obtained from thermogravimetric curves using the following differential methods: Friedman isoconversional and Freeman-Caroll, respectively integral methods: Flynn-Wall-Ozawa, Kissinger-Akahira-Sunose, Starink and Tang. Keywords: piroxicam, thermal stability, kinetic study, non-isothermal conditions

Issue: 2015, Volume 66, Issue 11

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