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https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
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Revista de Chimie (Rev. Chim.), Year 2015, Volume 66, Issue 12,





GLADIOLA TANTARU, LUMINITA MARIN, MADALINA VIERIU, ALINA DIANA PANAINTE, ANTONIA POIATA, MIHAI APOSTU, NELA BIBIRE
The Influence of Structure on Antibacterial Activity of Some New Aniline Derived Schiff Bases

Abstract:

This paper presents the synthesis of some Schiff bases with potential antimicrobial activity. A new ligand was synthetized through the condensation reaction of aniline with various aldehydes: benzaldehyde, salicylic aldehyde, p-hydroxy-benzaldehyde and vanillin. The chemical structure was confirmed by 1H-NMR and IR spectroscopy. The antimicrobial activity of the Schiff bases and their precursors were tested in comparison with Tetracycline, Nystatin and Ampicillin upon the following strains: Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922) and Candida albicans (ATCC 1023). The compounds were found to be very active against gram-positive and gram-negative bacteria. Some conclusions regarding the chemical structure - antimicrobial activity relationship have been drawn. Keywords: aniline, Schiff base, antimicrobial activity


Issue: 2015, Volume 66, Issue 12
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